Massive intravascular hemolysis with organ failure due to Clostridium perfringens: evidence of intracytoplasmic C. perfringens.
نویسندگان
چکیده
A 66-year-old diabetic man presented with breathlessness, vomiting, and fever. His initial blood count demonstrated hemoglobin 135 g/L (130-175), platelets 155 3 10/L (150-400), and white blood cells 18.3 3 10/L (4-11). His hemoglobin fell rapidly over 6 hours to 44 g/L, platelets fell to 39 3 10/L, and white blood cells increased to 20.4 3 10/L. D-Dimer assay was 35 857 ng/mL (,250), fibrinogen was 0.3 g/L (1.5-4), and international normalized ratio was 3.6, supporting a diagnosis of disseminated intravascular coagulopathy. The blood serum turned black secondary to hemolysis. The peripheral blood film showed microspherocytes with erythrophagocytosis and thrombocytopaenia. Neutrophils showed left shift and vacuolation. Two band forms were identified with an intracytoplasmic bacillus. Despite intensive care support and intravenous antibiotics, the patient arrested and was pronounced dead 6 hours following admission. Subsequently, blood samples cultured a Clostridium perfringens isolate.
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1. Chaplin H, Glazer H, Hockett R, Krewson L, Murphy K. Abdominal pain, total intravascular hemolysis and death in 53-year-old woman. Am J Med 1990; 88:66774. 2. Hübl W, Mostbeck B, Hartleb H, Pointner H, Kofler K, Bayer PM. Investigation of the pathogenesis of massive hemolysis in a case of Clostridium perfringens septicemia. Ann Hematol 1993; 67:145-7. 3. Pun K, Wehner J. Abdominal pain and m...
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عنوان ژورنال:
- Blood
دوره 122 3 شماره
صفحات -
تاریخ انتشار 2013